Dr. Holger Prokisch is the head of the research group “Genetics of Mitochondrial Diseases” at the Institute of Human Genetics, School of Medicine, TUM Klinikum, and the Institute of Neurogenomics, Department of Computational Health, Helmholtz Munich, Germany

Holger Prokisch explores genetic variation in both rare and common diseases with a functional focus on mitochondria-related disease mechanisms.
His group was successful in integrating genomic approaches with detailed functional biochemical investigations.
Holger Prokisch contributed to the discovery of more than 80 novel disease genes, by applying whole exome and genome sequencing. He extended the diagnostic toolbox by establishing RNA-sequencing and proteomics pipelines for the diagnosis of Mendelian diseases. Much of his work is focused on advanced diagnostics by multi-omics integration. He coordinates the German and Eurasian network for mitochondrial disorders mitoNET and GENOMIT (EJP RD).
In 2024 Holger Prokisch was awarded with the GfH most prestigious award, the GfH Medal of Honor. The GfH Medal of Honor recognizes human geneticists who have made significant scientific contributions, advanced the field of human genetics, and demonstrated exemplary character in Germany.