João B. Vicente,

Earned his European Label PhD in Biochemistry from NOVA University of Lisbon (Portugal) and Sapienza University of Rome (Italy) in 2007. After a post-doc in Stanford University (USA) and a researcher position at iMed.ULisboa and the School of Pharmacy, Lisbon University (Portugal), he started a position as Auxiliary Investigator in the Macromolecular Crystallography Unit at NOVA Instituto de Tecnologia Química e Biológica António Xavier (Portugal).
Currently, Vicente leads the Applied Protein Biochemistry Lab at ITQB. His research team combines protein biochemistry and biophysics with structural biology to investigate molecular details of protein function and structure, and to tailor and target proteins with biotechnological applications.
One of the main research interests is the study of molecular mechanisms underlying human hydrogen sulfide (H2S) metabolism. Particularly, his team is interested in understanding how the metabolic pathways leading to the production and breakdown of H2S are regulated by endogenous physiologically relevant modulators. Through a network of collaborators, he aims to position these metabolic pathways and their regulatory mechanisms as key determinants in the context of various human diseases. Moreover, he is committed to the discovery and development of pharmacological and diagnostics tools to improve therapeutics.